解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
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神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
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毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Metastatic breast cancer is incurable. The goal of this study was to develop a positron emission tomography (PET)/near-infrared fluorescent (NIRF) probe for imaging CD105 expression in breast cancer experimental lung metastasis. TRC105, a chimeric anti-CD105 antibody, was dual-labeled with a NIRF dye (IRDye 800CW) and...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp300277f
更新日期:2012-08-06 00:00:00
abstract::Though metastasis is considered an inefficient process, over 90% of cancer related deaths are attributed to the formation of secondary tumors. Thus, eliminating circulating cancer cells could lead to improved patient survival. This study was aimed at exploiting the interactions of cancer cells with selectins under flo...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp300073j
更新日期:2012-08-06 00:00:00
abstract::Porous silicon microparticles presenting pathogen-associated molecular patterns mimic pathogens, enhancing internalization of the microparticles and activation of antigen presenting dendritic cells. We demonstrate abundant uptake of microparticles bound by the TLR-4 ligands LPS and MPL by murine bone marrow-derived de...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp3001292
更新日期:2012-07-02 00:00:00
abstract::An ability to estimate the maximum flux of a xenobiotic across skin is desirable from the perspective of both drug delivery and toxicology. While there is an abundance of mathematical models describing the estimation of drug permeability coefficients, there are relatively few that focus on the maximum flux. This artic...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp300146m
更新日期:2012-07-02 00:00:00
abstract::Near-infrared (NIR)-to-visible upconversion nanoparticle (UCNP) has shown promising prospects in photodynamic therapy (PDT) as a drug carrier or energy donor. In this work, a photosensitizer pyropheophorbide a (Ppa) and RGD peptide c(RGDyK) comodified chitosan-wrapped NaYF(4):Yb/Er upconversion nanoparticle UCNP-Ppa-R...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200590y
更新日期:2012-06-04 00:00:00
abstract::Due to the aging of the population, the incidence of neurodegenerative diseases, such as Parkinson's and Alzheimer's, is expected to grow and, hence, the demand for adequate treatment modalities. However, the delivery of medicines into the brain for the treatment of brain-related diseases is hampered by the presence o...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200621v
更新日期:2012-06-04 00:00:00
abstract::Safe and effective gene delivery is essential to the success of gene therapy. We synthesized and characterized a novel nonviral gene delivery system in which folate (FA) molecules were functioned as blockers on cationic polyrotaxanes (PR) composed of poly(ethylenimine) (PEI)(600)-grafted α-cyclodextrin rings linearize...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200315c
更新日期:2012-05-07 00:00:00
abstract::The goal of this study was to develop a (66)Ga-based positron emission tomography (PET) tracer for noninvasive imaging of CD105 expression during tumor angiogenesis, a hallmark of cancer. (66)Ga was produced using a cyclotron with (nat)Zn or isotopically enriched (66)Zn targets. TRC105, a chimeric anti-CD105 monoclona...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp300019c
更新日期:2012-05-07 00:00:00
abstract::Nonviral gene delivery has seen limited clinical application due in part to the inefficiency with which most nonviral vehicles navigate the intracellular gene delivery pathway. One key problem is the inability of most DNA-packaging materials to release DNA and enable its efficient transcription. Thus, our aim was to d...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200373p
更新日期:2012-05-07 00:00:00
abstract::Amphotericin B (AmB) is a lifesaving polyene antibiotic used widely to treat deep-seated mycoses. Both the pharmaceutical effectiveness as well as toxic side effects depend on molecular organization of the drug. In the present study, we analyzed steady-state fluorescence, fluorescence anisotropy spectra, fluorescence ...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp300143n
更新日期:2012-05-07 00:00:00
abstract::The objective of this study was to enhance oral mucosal permeation of fenretinide by coincorporation of propylene glycol (PG) and menthol in fenretinide/Eudragit RL PO mucoadhesive patches. Fenretinide is an extremely hydrophobic chemopreventive compound with poor tissue permeability. Coincorporation of 5-10 wt % PG (...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200655k
更新日期:2012-04-02 00:00:00
abstract::The present work investigates the influence of electrostatic surface potential distribution of monoclonal antibodies (MAbs) on intermolecular interactions and viscosity. Electrostatic models suggest MAb-1 has a less uniform surface charge distribution than MAb-2. The patches of positive and negative potential on MAb-1...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200566k
更新日期:2012-04-02 00:00:00
abstract::The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds, including bile acids, steroid conjugates, hormones, and drugs, including the 3-hydroxy-3-methylglutaryl Co-A reducta...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200629s
更新日期:2012-04-02 00:00:00
abstract::Solid-state hydrogen-deuterium exchange with mass spectrometric analysis (ssHDX) is a promising method for characterizing proteins in amorphous solids. Though analysis of HDX kinetics is informative and well-established in solution, application of these methods to solid samples is complicated by possible heterogeneiti...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp2004093
更新日期:2012-04-02 00:00:00
abstract::Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5, or 25 mg of each drug were administered daily for 90 days to rhesus macaques (n = 4/group). Single inhalations or intra...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp300043f
更新日期:2012-04-02 00:00:00
abstract::Biophysical tools have been invaluable in formulating therapeutic proteins. These tools characterize protein stability rapidly in a variety of solution conditions, but in general, the techniques lack the ability to discern site-specific information to probe how solution environment acts to stabilize or destabilize the...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp2004109
更新日期:2012-04-02 00:00:00
abstract::Indocyanine green (ICG) is a conventional dye that can be used in clinical near-infrared (NIR) imaging, and it is also an effective light absorber for laser-mediated photothermal therapy. However, applications of ICG were limited due to its fast degradation in aqueous media and quick clearance from the body. Herein, a...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200526m
更新日期:2012-03-05 00:00:00
abstract::Cancer is a leading cause of death within developed nations, and part of this morbidity is due to difficulties associated with its treatment. Currently, anticancer therapy relies heavily upon the administration of small molecule cytotoxic drugs that attack both cancerous and noncancerous cells due to limited selectivi...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章,评审
doi:10.1021/mp2005966
更新日期:2012-03-05 00:00:00
abstract::The killing efficacy of doxorubicin from liposome-based delivery carriers has been shown to correlate strongly with its intracellular trafficking and, in particular, its fast and extensive release from the delivery carrier. However, previously explored pH-triggered mechanisms that were designed to become activated dur...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200079y
更新日期:2011-12-05 00:00:00
abstract::It is likely that drug resistance evolves after transformation. Exactly how these resistant cells arise is uncertain. This review outlines how the evolution of individual human cancers may be inferred by comparing genomic variation from different parts of the same tumor. The past of a tumor may help predict its respon...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章,评审
doi:10.1021/mp200256n
更新日期:2011-12-05 00:00:00
abstract::Encapsulation and release behavior of a water-insoluble drug, magnolol, using a core-shell polysaccharide-based nanoparticle, manipulating the cellular internalization and controlled cytotoxic effect of magnolol-loaded nanoparticles over the A10 vascular smooth muscle cells (VSMCs) was reported. A magnolol-polyvinylpy...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200257y
更新日期:2011-12-05 00:00:00
abstract::The current regimen of factor IX (FIX) injection is of an episodic format, which leads to limited efficacy. A sustained release dosage form is beneficial in terms of reducing the injection frequency and improving the therapeutic effectiveness. The aim of this study was to formulate a new microsphere form of a FIX-cont...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200133s
更新日期:2011-10-03 00:00:00
abstract::The systemic pharmacokinetics and pharmacodynamics of small molecules are determined by subcellular transport phenomena. Although approaches used to study the subcellular distribution of small molecules have gradually evolved over the past several decades, experimental analysis and prediction of cellular pharmacokinet...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章,评审
doi:10.1021/mp200092v
更新日期:2011-10-03 00:00:00
abstract::The use of adult stem cells for therapeutic purposes has met with great success in recent years. Among several types of adult stem cells, mesenchymal stem cells (MSCs) derived from bone marrow (BM) and other sources have gained popularity for basic research and clinical applications because of their therapeutic potent...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章,评审
doi:10.1021/mp200135e
更新日期:2011-10-03 00:00:00
abstract::Fexofenadine is a nonsedative antihistamine that exhibits good oral bioavailability despite its zwitterionic chemical structure and efflux by P-gp. Evidence exists that multiple uptake and efflux transporters play a role in hepatic disposition of fexofenadine. However, the roles of specific transporters and their inte...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200026v
更新日期:2011-10-03 00:00:00
abstract::Aerosol glucocorticoid medications have become more and more important in treating BA (bronchial asthma). Although these agents are dosed to directly target airway inflammation, adrenocortical suppression and other systematic effects are still seen. To tackle this problem in a novel way, two L-carnitine ester derivati...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp100412z
更新日期:2011-10-03 00:00:00
abstract::Because of its biocompatibility and ability to accommodate a variety of payloads from poorly soluble drugs to biomolecules, porous silicon (PSi) is a lucrative material for the development of carriers for particle-mediated drug delivery. We report a successful direct one-step (18)F-radiolabeling of three types of PSi ...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp2001654
更新日期:2011-10-03 00:00:00
abstract::Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles have a proven capacity for drug solubilization and have entered phase III clinical trials as a substitute for Cremophor EL in the delivery of paclitaxel in cancer therapy. PEG-b-PLA is less toxic than Cremophor EL, enabling a doubling of paclitaxel...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp2000549
更新日期:2011-08-01 00:00:00
abstract::Progesterone receptor (PR) is a significant biomarker in diseases such as endometriosis and breast, ovarian, and uterine cancers that is associated with disease prognosis and therapeutic efficacy. While receptor status is currently determined by immunohistochemistry assays, the development of noninvasive PR imaging ag...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200219e
更新日期:2011-08-01 00:00:00
abstract::In this study, the dissolution properties of celecoxib (CX) solid dispersions manufactured from Eudragit 4155F and polyvinylpyrrolidone (PVP) were evaluated. Hot-melt extrusion (HME) technology was used to prepare amorphous solid dispersions of drug/polymer binary systems at different mass ratios. The drug concentrati...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200157b
更新日期:2011-08-01 00:00:00
abstract::Hyaluronan (HA) is a biocompatible and biodegradable linear polysaccharide which is of interest for tumor targeting through cell surface CD44 receptors. HA binds with high affinity to CD44 receptors, which are overexpressed in many tumors and involved in cancer metastasis. In the present study, we investigated the imp...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp2000428
更新日期:2011-08-01 00:00:00
abstract::Polymer therapeutics have shown promise as tumor-targeted drug delivery systems in mice. The multivalency of polymers allows the attachment of different functional agents to a polymeric backbone, including chemotherapeutic and antiangiogenic drugs, as well as targeting moieties, such as the bone-targeting agent alendr...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200083n
更新日期:2011-08-01 00:00:00
abstract::This study investigated the role of the prostaglandin (PG) pathway in locally applied, simvastatin-induced oral bone growth. The possibility of enhancing long-term bone augmentation with an alendronate-based carrier was initiated. Mandibles of 44 mature female rats were treated bilaterally with the following combinati...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200045p
更新日期:2011-08-01 00:00:00
abstract::Targeted gene delivery using nonviral vectors is a highly touted scheme to reduce the potential for toxic or immunological side effects by reducing dose. In previous reports, TAT polyplexes with DNA have shown relatively poor gene delivery. The transfection efficiency has been enhanced by condensing TAT/DNA complexes ...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp100393j
更新日期:2011-06-06 00:00:00
abstract::Cholestasis is a significant risk factor for immediate hepatic failure due to ischemia reperfusion (I/R) injury in patients undergoing liver surgery or transplantation. We recently demonstrated that inhibition of Hedgehog (Hh) signaling with cyclopamine (CYA) before I/R prevents liver injury. In this study we hypothes...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200115v
更新日期:2011-06-06 00:00:00
abstract::TGX-221 is a highly potent phosphoinositide 3-kinase β (PI3Kβ) inhibitor that holds great promise as a novel chemotherapeutic agent to treat prostate cancer. However, poor solubility and lack of targetability limit its therapeutic applications. The objective of this present study is to develop a peptide-drug conjugate...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200007b
更新日期:2011-06-06 00:00:00
abstract::Tumor-associated inflammation has been linked to angiogenesis, metastasis and poor prognosis. The 18 kDa translocator protein (TSPO), also known as the peripheral benzodiazepine receptor (PBR), is expressed in activated immune cells such as macrophages, but also in a number of cancer cell lines such as those of breast...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp100433c
更新日期:2011-06-06 00:00:00
abstract::Noninvasive measurement of human islet cell mass in pancreas or following islet transplantation by nuclear imaging has yet to be achieved. It has been shown using mouse tumor models that pretargeting imaging strategies are sensitive and can greatly increase target to nontarget signal ratios. The objective now is to de...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp100382m
更新日期:2011-06-06 00:00:00
abstract::Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations to ensure their bioavailability. Here, stimulated Raman scattering (SRS) microscopy, a rece...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp200122w
更新日期:2011-06-06 00:00:00
abstract::Despite being widely used in the clinical setting for sentinel lymph node detection (SLND), (99m)Tc-based colloids (e.g., (99m)Tc-human serum albumin colloids) present a set of properties that are far from ideal. Aiming to design novel compounds with improved biological properties, we describe herein the first class o...
journal_title:Molecular pharmaceutics
pub_type: 杂志文章
doi:10.1021/mp100425p
更新日期:2011-04-04 00:00:00